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Esto incluye a los nios menores de cinco aos, los adultos a partir de los 65, las mujeres embarazadas, los pacientes de afecciones mdicas o inmunosupresoras crnicas, tales como pacientes de quimioterapia, y las personas menores de 19 aos que reciben terapia con aspirina a largo plazo.

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5 Rangasamy et al report that a greater proportion of colonic and distal CD has been diagnosed in older patients, 3 whereas younger patients have predominantly ileal disease.

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Tambin se preocupa por el uso del medicamento fuera del contexto de la receta, en que los mdicos potencialmente la receten a mujeres jvenes, embarazadas o lactantes u otros tipos de pacientes que an no se han incluido en ensayos clnicos.

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